Because renal function deteriorates with age, even in the seemingly healthy. Use cefotetan with caution in patients with renal impairment or renal failure because the drug is eliminated via renal mechanisms. Patients 70 kg or on dialysis may require additional dosage. In clinical studies, the following adverse effects were considered related to cefotetan therapy. Dailymed cefotetan injection, powder, for solution. Table 1 renal dosage adjustment antimicrobial dosing regimen with normal renal function dosing regimen with crcl less than 50 mlmin dosing. Cefotan cefotetan for injection, usp is supplied in vials containing 80 mg 3. Over 125 drugs have been associated with immune hemolysis. Cefotaxime, cefotetan, cefotiam, cefoxitin, cefprozil, ceftazidime, ceftizoxime, ceftriaxone, cefuroxime axetil, cefuroxime sodium, cephalexin, cephradine. The information on dosage adjustments in renal impairment given in this book is based on cockcroftgault creatinine clearance and not egfr, since the majority.
The renal drug handbook third edition edited by caroline ashley and aileen currie uk renal pharmacy group foreword by. The information on dosage adjustments in renal impairment given in this book is based on. Vancomycin is a timedependent antibiotic, so shorten administration interval to q6h in patients with normal renal. Cefotetan pharmacokinetics in volunteers with various. The renal drug handbook the st georges hospital, adult critical.
Ceftriaxone ceftriaxone dose, indications, adverse. The authors make no claims of the accuracy of the information contained herein. Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organism. Pharmacokinetics of cefotetan in normal subjects and. The usual adult dosage is 1 gram g or 2 grams of cefotan cefotetan for injection, usp administered intravenously or intramuscularly. Cefotetan side effects, dosage, interactions drugs everyday health. Not for use in patients with ascites, burns covering 20% of total body surface area, cystic fibrosis, endstage renal disease, endocarditis, infants, mycobacterial infections, or. Specific populations patients with renal impairment in volunteers with reduced renal function, the plasma halflife of cefotetan is prolonged.
This guide succeeds at providing busy healthcare providers with updated and evidencebased information on dosing and monitoring commonly used medications in patients with renal. Stanford health care aminoglycoside dosing guideline. This new book addresses the persistent and challenging problem of dosing medications for patients with renal insufficiency and dysfunction. Generally, a prevalent renal excretion of a given drug predicts a clinically relevant rrt removal, and drug dosing adjustment is commonly required if the ec fractional cl is higher than 25%. Maxipime cefepime dosing, indications, interactions. Abacavir abacavir lamivudine abacavir lamivudine zidovudine acarbose acebutolol acetaminophen acetazolamide acetohexamide acetohydroxamic acid acetylsalicylic acid aspirin acrivastine acyclovir adefovir adenosine albuterol inhaled albuterol oral alfentanil alfentanil allopurinol alprazolam alteplase tissuetype plasminogen activator.
In patients with both hepatic and severe renal impairment, cefoperazone dosage. Dosing guidelines for varying degrees of renal impairment are stated accordingly. For patients with impaired renal function, re dosing. However, serum drug concentrations should be monitored if high dosages are used i. It is a white to pale yellow powder which is very soluble in water. Welcome to the fifth edition of the renal drug handbook. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Antimicrobial agents antibacterial antibiotics antifungal antibiotics antimycobacterial antibiotics antiparasitic antibiotics antiviral agents. Renal dose adjustment guidance the following table can be utilized to determine if adjustments are needed to antimicrobial surgical prophylaxis for both preop and postop dosing.
Medical information for cefotetan on pediatric oncall including mechanism, indication, contraindications, dosing, adverse effect, interaction. In patients undergoing cesarean section, the dose should be administered as soon as the umbilical cord is clamped. There is a linear correlation between the systemic clearance of cefotetan. Results of a multicenter comparative study of single dose cefotetan and multiple dose. Cefotan cefotetan disodium injection, powder, for solution. Detailed cefotetan dosage information for adults and children. Dailymed cefotetan cefotetan disodium injection, powder. Maypotentiate theeffectsof anticoagulants andqtheriskofbleeding. Find patient medical information for cefotetan in dextrose intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Re dosing guidelines for complex cases cases longer than 4. Data sources include ibm watson micromedex updated 28 feb 2020, cerner multum updated 2 mar 2020, wolters kluwer updated. Abacavir abacavir lamivudine abacavir lamivudine zidovudine acarbose acebutolol acetaminophen acetazolamide acetohexamide acetohydroxamic acid acetylsalicylic acid aspirin acrivastine. Cefotetan side effects, dosage, interactions drugs.
General renal dosing guidelines agents not listed below click here for a specialized list of other renal medication dosing not listed in the alphabetical main section simple renal dosing guidelines. Concentrations of cefotetan and cefotetan tautomer in plasma. Dosage reductions are recommended in these patients. Lozier, pierre noel, in clinical immunology fifth edition, 2019. To reduce the development of drugresistant bacteria and maintain the effectiveness of cefotetan for injection and dextrose injection and other antibacterial drugs, cefotetan. Ceftriaxone 250 mg im as a single dose plus azithromycin 2 g po as a single dose should be used in those with treatment failure after treatment with alternative regimen of cefixime and.
Drug dosing adjustments in patients with chronic kidney disease myrna y. Saturable aminoglycosides uptake in renal tubule cell and inner ear. Cefotaxime, cefotetan, cefoxitin, cefpodoxime, cefprozil, ceftazidime, ceftibuten, ceftizoxime, ceftriaxone, cefuroxime axetil, cefuroxime sodium, celiprolol. Cefotetan for injection, usp is supplied in vials containing 80 mg 3. Cefotetan is a semisynthetic, broadspectrum, betalactamaseresistant, secondgeneration cephalosporin antibiotic derived from cephalosporium. The most current version of the renal dosage adjustment guidelines for antimicrobials and associated. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Cefotetan mechanism, indication, contraindications. Renal drug dosage adjustment guidelines for adults milligrams dosing interval in hours unless otherwise specified doses are for 70 kg adults. Cefotetan cefotetan disodium dose, indications, adverse. G mycetin, garamycin gentamicin dosing, indications. Dosing guidelines for complex cases cases longer than 4 hours the following are re. Drug dosing adjustments in patients with chronic kidney.
A single dose of aminoglycoside results in significantly lower renal cortical tissue concentration compared to the same total dose. Herb joinerbey nd, in the clinicians handbook of natural medicine third. The mean terminal halflife increases with declining renal function, from approximately 4 hours in volunteers with normal renal function to about 10 hours in those with moderate renal. Renal dosage adjustment guidelines for antimicrobials the. Cefepime, cefotaxime, cefotetan, cefotiam, cefoxitin, cefprozil, ceftazidime, ceftizoxime, ceftriaxone, cefuroxime axetil, cefuroxime sodium, cephalexin. The mean cumulative urinary recovery of cefotetan in the 24h urine was 83. Empiric dosing should be continued using total body weight for a total daily dose of 20 30 mgkgday with a single dose cap of 3gm. Cefotetan disodium reference guide for safe and effective use from the american. Cefotan cefotetan disodium injection, powder, for solution cefotan cefotetan disodium injection, powder, for solution if this spl contains inactivated ndcs listed by the fda. Cefotetan is a cephalosporin sef a low spor in antibiotic. Twentysix volunteers with various degrees of renal function were given a single 1g dose of cefotetan intravenously over 30 min. Concurrentuseof amino glycosides mayqtheriskofnephrotoxicity. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function see dosage and administration, impaired renal function.
Includes dosages for bacterial infection, urinary tract infection, skin or soft tissue infection and more. Cefotetan fda prescribing information, side effects and uses. The mean terminal halflife increases with declining renal function, from approximately 4 hours in volunteers with normal renal function to about 10 hours in those with moderate renal impairment. For renally excreted drugs with a narrow therapeutic index, the total daily maintenance dose may be reduced either by decreasing the dose or by increasing the dosing interval, or sometimes by a combination of both. A guide to understanding antimicrobial drug dosing in. Brogard jm, kopferschmitt j, spach mo, et al cefamandole pharmacokinetics and dosage adjustments in relation to renal function. Munar, pharmd, bcps, and harleen singh, pharmd oregon state university college of pharmacy, portland, oregon. The total daily dose should be reduced when mefoxin is administered to patients with transient or persistent reduction of urinary output due to renal insufficiency see dosage and. Dosage of cefotetan for adults with renal impairment9110157. Renal function declines with age as a result of the anatomical and physiological changes that occur with aging. Use with caution in patients with renal impairment. Dailymed cefotetan and dextrose injection, solution.
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